30 days old

Sr Associate Scientist - Discovery Proteomics

Amgen
South San Francisco, CA 94080
  • Job Code
    118833073
Amgen

Job ID: R-95485
Location: South San Francisco, CA, US 94083

Amgen is a values based organization with a powerful sense of shared purpose toward our mission: to serve patients. At our San Francisco facilities, we provide the capabilities, resources, and rewards of a global enterprise, while maintaining the entrepreneurialism and verve that marked our early days as a biotechnology pioneer. We encourage our team members to have fulfilling and meaningful careers through challenging assignments, career development, and valuable opportunities such as this:

Amgen is seeking a talented and motivated Senior Associate Scientist with expertise in liquid chromatography/mass spectrometry-based proteomics to join the Discovery Attribute Sciences team at South San Francisco. The successful candidate will conduct quantitative discovery and targeted proteomics studies in support of Amgen's Induced Proximity Platform, with a focus on the biological characterization of novel modality early candidates including proteolysis targeting chimeras (PROTACs). Demonstrated expertise in quantitative mass spectrometry-based proteomic technologies is essential.

Discovery Attribute Sciences is tasked with developing and implementing proteomic and protein characterization technologies in support of Amgen's early discovery pipeline.

Position Responsibilities

This role will enable Amgen's preclinical pipeline through delivery of innovation and technical expertise. Responsibilities will include experimental design and implementation of complex proteomics workflows involving sample preparation, chromatographic separations, and mass spectrometric analysis. Quantitative discovery as well as targeted workflows will be employed involving label-free analyses, isobaric labeling, selected reaction monitoring, and data-independent acquisition (DIA). The successful candidate will be expected to work across both genomic and proteomic platforms for data integration and mining, utilizing available external resources where appropriate.

Basic Qualifications

Master's degree and 3 years of scientific experience

OR

Bachelor's degree and 5 years of scientific experience

Preferred Qualifications

Doctorate degree or Doctorate degree completed by June 2020

Academic and/or industrial training in Proteomics and Mass Spectrometry or other relevant scientific fields

Hands-on experience with deep proteomic analysis of tissues/cell cultures utilizing modern mass spectrometric instrumentation/software (e.g. Thermo Orbitrap and Sciex TripleTOF platforms), sample processing techniques (e.g. isobaric labeling), data acquisition schemes (e.g. data-independent acquisition) and data processing pipelines (e.g. Proteome Discoverer, Spectronaut, Skyline)

Experience in chemical proteomics, protein-protein interactome studies, or mining public proteomic databases

Proven track record of independent critical thinking and scientific achievement

Strong background in biology or chemistry, especially as it pertains to human disease in the fields of Immunology/Oncology, Inflammation, and Cardiometabolic Disease

Strong verbal and written skills, and an ability to work independently as well as in small teams

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

PI118833073

<b>Amgen</b><br/><br/><b>Job ID: </b>R-95485<br/><b>Location: </b>South San Francisco, CA, US 94083<br/><br/>Amgen is a values based organization with a powerful sense of shared purpose toward our mission: to serve patients. At our San Francisco facilities, we provide the capabilities, resources, and rewards of a global enterprise, while maintaining the entrepreneurialism and verve that marked our early days as a biotechnology pioneer. We encourage our team members to have fulfilling and meaningful careers through challenging assignments, career development, and valuable opportunities such as this:<br><br>Amgen is seeking a talented and motivated Senior Associate Scientist with expertise in liquid chromatography/mass spectrometry-based proteomics to join the Discovery Attribute Sciences team at South San Francisco. The successful candidate will conduct quantitative discovery and targeted proteomics studies in support of Amgen's Induced Proximity Platform, with a focus on the biological characterization of novel modality early candidates including proteolysis targeting chimeras (PROTACs). Demonstrated expertise in quantitative mass spectrometry-based proteomic technologies is essential.<br><br>Discovery Attribute Sciences is tasked with developing and implementing proteomic and protein characterization technologies in support of Amgen's early discovery pipeline.<br><br><b>Position Responsibilities</b><br><br>This role will enable Amgen's preclinical pipeline through delivery of innovation and technical expertise. Responsibilities will include experimental design and implementation of complex proteomics workflows involving sample preparation, chromatographic separations, and mass spectrometric analysis. Quantitative discovery as well as targeted workflows will be employed involving label-free analyses, isobaric labeling, selected reaction monitoring, and data-independent acquisition (DIA). The successful candidate will be expected to work across both genomic and proteomic platforms for data integration and mining, utilizing available external resources where appropriate.<br><br><b>Basic Qualifications</b><br><br>Master's degree and 3 years of scientific experience<br><br>OR<br><br>Bachelor's degree and 5 years of scientific experience<br><br><b>Preferred Qualifications</b><br><br>Doctorate degree or Doctorate degree completed by June 2020<br><br>Academic and/or industrial training in Proteomics and Mass Spectrometry or other relevant scientific fields<br><br>Hands-on experience with deep proteomic analysis of tissues/cell cultures utilizing modern mass spectrometric instrumentation/software (e.g. Thermo Orbitrap and Sciex TripleTOF platforms), sample processing techniques (e.g. isobaric labeling), data acquisition schemes (e.g. data-independent acquisition) and data processing pipelines (e.g. Proteome Discoverer, Spectronaut, Skyline)<br><br>Experience in chemical proteomics, protein-protein interactome studies, or mining public proteomic databases<br><br>Proven track record of independent critical thinking and scientific achievement<br><br>Strong background in biology or chemistry, especially as it pertains to human disease in the fields of Immunology/Oncology, Inflammation, and Cardiometabolic Disease<br><br>Strong verbal and written skills, and an ability to work independently as well as in small teams<br><br>Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.<br><br>We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.<br><br>Join Us <br> <br> If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. <br> <br> Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. <br> <br> As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. <br> <br> Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. <br> <br> Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.<br/><br/> <img src="https://analytics.click2apply.net/v/oz411NCqq4q7s6d4ulX6R"> <p>PI118833073</p>

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Posted: 2020-03-07 Expires: 2020-04-07

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Sr Associate Scientist - Discovery Proteomics

Amgen
South San Francisco, CA 94080

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