14 days old

Mammalian Cell Engineering for Multispecifics

Amgen
Thousand Oaks, CA 91360
  • Job Code
    117761662
Amgen

Job ID: R-92896
Location: Thousand Oaks, CA, US 91360

Postdoctoral Fellow: Mammalian Cell Engineering for Multispecifics

The Amgen Postdoctoral Program is committed to providing future scientists with an enriched environment to encourage innovation that will contribute to the generation of human therapeutics.

We have an exciting new opening for a postdoctoral researcher in the Protein Engineering group within the larger Amgen Biologics Optimization department. This research project is aimed at investigating the expression pathway of novel and non-native multispecific molecules (bispecific antibodies, trispecific antibodies, etc). Understanding and improving how standard cellular machinery (transcription, translation, folding, assembly, and secretion) is influenced by these non-native molecules will have broad and practical implications for the field of protein engineering and design.

The successful applicant will perform independent research within the context of a highly collaborative environment and with access to state-of-the-art technologies and resources focused in cell biology and protein engineering but also mammalian expression, protein purification, and genomics.

The postdoctoral fellow will not only obtain scientific training but also be directly exposed to the industrial environment at Amgen. The postdoc will participate at group meetings and seminars at Amgen. This postdoc project is designed to not only provide opportunity for descriptive, basic research that can be published in top tier journals, but also establish a new tool box with enhanced host cell lines key to support multispecific molecules in Amgen's pipeline. Naturally, it will also provide the postdoc a possibility of scientific excellence and industrial recognition.

The assignment length is expected to be 3 years long.

Basic Qualifications

  • PhD. or Doctorate degree to be completed by XXXX 2020.


Preferred Qualifications

  • PhD in Molecular Biology, Cell Biology, Genomics, or Biochemistry.
  • Proven expertise and publications using current gene-editing technologies, including CRISPR/Cas9 mediated genome engineering, as applied to mammalian cell systems.
  • Proven expertise with Next Generation Sequencing and data analysis.
  • Proficiencies in mammalian cell culturing and molecular biology technologies. Understanding of quaternary structures of proteins would be a plus.
  • Record of independent critical thinking and the ability to design, execute, and interpret experiments, as exemplified by high quality peer-reviewed publications.


Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

PI117761662

<b>Amgen</b><br/><br/><b>Job ID: </b>R-92896<br/><b>Location: </b>Thousand Oaks, CA, US 91360<br/><br/><b><b>Postdoctoral Fellow: <b>Mammalian Cell Engineering for Multispecifics</b></b></b><br><br>The Amgen Postdoctoral Program is committed to providing future scientists with an enriched environment to encourage innovation that will contribute to the generation of human therapeutics.<br><br>We have an exciting new opening for a postdoctoral researcher in the Protein Engineering group within the larger Amgen Biologics Optimization department. This research project is aimed at investigating the expression pathway of novel and non-native multispecific molecules (bispecific antibodies, trispecific antibodies, etc). Understanding and improving how standard cellular machinery (transcription, translation, folding, assembly, and secretion) is influenced by these non-native molecules will have broad and practical implications for the field of protein engineering and design.<br><br>The successful applicant will perform independent research within the context of a highly collaborative environment and with access to state-of-the-art technologies and resources focused in cell biology and protein engineering but also mammalian expression, protein purification, and genomics.<br><br>The postdoctoral fellow will not only obtain scientific training but also be directly exposed to the industrial environment at Amgen. The postdoc will participate at group meetings and seminars at Amgen. This postdoc project is designed to not only provide opportunity for descriptive, basic research that can be published in top tier journals, but also establish a new tool box with enhanced host cell lines key to support multispecific molecules in Amgen's pipeline. Naturally, it will also provide the postdoc a possibility of scientific excellence and industrial recognition.<br><br>The assignment length is expected to be 3 years long.<br><br><b>Basic Qualifications</b><br><br><ul><li>PhD. or Doctorate degree to be completed by XXXX 2020.</li></ul><br><br><b>Preferred Qualifications</b><br><br><ul><li>PhD in Molecular Biology, Cell Biology, Genomics, or Biochemistry.</li><li>Proven expertise and publications using current gene-editing technologies, including CRISPR/Cas9 mediated genome engineering, as applied to mammalian cell systems.</li><li>Proven expertise with Next Generation Sequencing and data analysis.</li><li>Proficiencies in mammalian cell culturing and molecular biology technologies. Understanding of quaternary structures of proteins would be a plus.</li><li>Record of independent critical thinking and the ability to design, execute, and interpret experiments, as exemplified by high quality peer-reviewed publications.</li></ul><br><br>Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do. <br><br><b>Join Us</b><br><br>If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. <br><br>Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. <br><br>As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. <br><br>Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. <br><br>Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. <br><br>Join Us <br> <br> If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. <br> <br> Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. <br> <br> As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. <br> <br> Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.<br/><br/> <img src="https://analytics.click2apply.net/v/E56ALASMwnkwfY5bsXman"> <p>PI117761662</p>

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Posted: 2020-02-04 Expires: 2020-03-06

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Mammalian Cell Engineering for Multispecifics

Amgen
Thousand Oaks, CA 91360

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