24 days old

Sr Associate Scientist - Cardiovascular

South San Francisco, CA 94080
  • Job Code

Job ID: R-92564
Location: South San Francisco, CA, US 94083

The Senior Associate Scientist will be directly responsible for executing in vivo cardiovascular preclinical studies with a goal to identify and characterize innovative drug therapies for the treatment of Heart failure. The successful candidate will work with preclinical in vivo models for testing therapeutic concepts and will need strong, hands-on technical skills. The Senior Associate Scientist will assist in designing in vivo experiments, drafting and implementing protocols, executing studies, organizing data, analyzing results, data recording and drafting reports. Expertise with in vivo and ex vivo cardiovascular techniques are essential.

Position Responsibilities

Executing in vivo cardiovascular PK/PD studies with a goal of identifying novel drug candidates. Extensive experience in heart failure models (e.g., surgical and genetic) models and ex vivo microvascular (e.g., mesenteric artery) vascular functional studies. Development of novel cardiovascular disease models. Cardiometabolic phenotyping of genetically modified rodents (i.e., knockout and transgenic lines).

In vivo assessment of cardiovascular hemodynamics using echocardiography, invasive hemodynamics (PV loop methodology). In vivo/ex vivo assay development/validation to evaluate the activity of novel compounds and reagents. Hands on experience with ELISA for biomarkers. Development of novel ELISA methods for biomarkers.

Daily animal monitoring, routine dose administration, tissue and fluid sampling, aseptic surgical preparation. Catheterization of major vessels for dosing/sampling

Working knowledge of the application/use of IACUC protocols

Basic Qualifications

Master's degree and 3 years of scientific experience


Bachelor's degree and 5 years of scientific experience

Preferred Qualifications

Doctorate degree or Doctorate degree completed by September 2020

Ph.D. or Master's in cardiovascular physiology, vascular biology, life sciences, or related field

Strong record in utilizing in-vivo/ex vivo cardiovascular models to study cardiovascular disease

Proficiency in Graph Pad, Excel and PowerPoint, as well as, with necessary tools for statistical data analysis

Excellent communication skills, troubleshooting skills, pro-active attitude and ability to work productively as part of high-performance teams.

A Fortune 150 company operating in nearly 100 countries around the world, we invest in highly skilled, dedicated and collaborative individuals who are ready to contribute to our mission in meaningful ways and make a difference in the lives of our patients. That's why, as a member of our cross functional, cross discipline team, we provide you with valuable opportunities to broaden your experience and maximize your potential. Focused on the industry's most compelling scientific discoveries and housed within industry leading facilities within the heart of the world's leading biotechnology hub, our colleagues are growing our pipeline through groundbreaking innovations. We believe in rewarding those who do rewarding work and are committed to providing careers that can help turn the tide of serious, life interrupting illnesses.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.



Posted: 2020-05-02 Expires: 2020-06-02

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Sr Associate Scientist - Cardiovascular

South San Francisco, CA 94080

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