The goal of this position will be the development of an efficient anti-cancer vaccine. The major problems correlated with cancer development include failure of the patient`s immune system to control tumor growth. My group has recently developed novel therapeutic viral vector based platforms to allow effective tumor antigen delivery to antigen presenting cell and initiation of specific immune response. These optimized vectors have a unique capsid structure that elicits cellular immune responses toward vector encoded antigens. The successful candidate will work on a project focused on the further development of viral immunotherapy for use in large animal models.
About the Department
The Hormel Institute, a biomedical research center of the University of Minnesota, was established in 1942 and has an excellent reputation and long history for producing world-class medical research. The Institute’s research success has resulted in a second major expansion of its research facilities and includes an additional new state-of-the-art laboratory building that opened in January 2016. The Hormel Institute offers its research scientists complete access to state-of-the- art cutting edge equipment that includes a cryo-electron microscope (Titan Krios and Tecnai G2 Spirit Biotwin); FACS cell sorter; confocal microscopy; flow cytometry; protein crystallography robotics and defraction system; nano-HPLC-AB SCIEX triple TOF 5600 mass spectrometry; Leica tissue processor, embedder and microtome; real-time PCR instrumentation; a Blue Gene/L and 3 racks of Linux GPU supercomputers for computational biology and bioinformatics; spectrophotometers; and Western blot imagers.
*THE HORMEL INSTITUTE IS LOCATED IN AUSTIN, MN, APPROXIMATELY 35 MILES SOUTHWEST OF ROCHESTER, MN, AND APPROXIMATELY 100 MILES SOUTH OF MINNEAPOLIS/ST. PAUL.*
A Ph.D. in Immunology, Cancer Gene Therapy, Oncolytic Virology or a related field is required along with extensive experience in immunology assays (primary DC and macrophages culture, Flow Cytometry, ELISA, ELISPOT, etc.) and xenograft animal models. The candidate must demonstrate effective verbal and written communication skills and be able to work in a team of scientists from different backgrounds.
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.