The Biological MS and Proteomics Core Facility at the University of Missouri-Kansas City offers protein identification and analysis, and differential quantitation MS services to our Faculty and regional Academic and Industrial investigators. Sample processing and analysis services include in-gel or in solution digestion, sample cleanup as needed by SPE, nano LC-MS (or multi-dimensional LC-mudpit), with data acquisition on LTQ Ion Trap or Q-Exactive HRMS system. We have Proteome Discoverer and Mascot licenses for database searching and reporting.
The Core Facility is seeking a qualified Senior Research Associate/Technologist with experience preparing and analyzing protein samples using nanoLC-tandem MS, hands-on experience with nanoLC chromatography, making capillary connections with fused silica and peek/stainless steel nano LC fittings; with column packing experience is preferred. Good troubleshooting skills and the ability to rapidly diagnose capillary column and autosampler problems to quickly restore LC operations are important. Familiarity with Proteome Discoverer and/or Mascot Search and Mascot Distiller, and other Proteomics data search platforms is also important. Experience managing search databases (full db and smaller custom db), setting up searches appropriately, generating results reports for clients are skills that will help your competitiveness for this position. A demonstrated knowledge of how different quantitative proteomics methods are performed is important, with enough experience to learn new quantitative methods quickly. Knowledge of Protein Hydrogen-Deuterium exchange theory would be beneficial, and some experience performing HDX on proteins is preferred. This Proteomics Facility is undergoing an expansion of services. We currently receive a variety of samples with diverse and interesting purposes, and we anticipate further substantial growth.
Assisting with all aspects of the processing and analyzing incoming samples will be the primary focus for this position. To facilitate ongoing service, duties will include keeping track of gases and chemicals and reagent inventories, as well as maintaining stocks of disposable materials needed for sample processing. Careful sample tracking by maintaining sample and instrument log book entries is essential.
Minimum qualifications include a Bachelor's degree in Chemistry, Biology, Biochemistry, or related life sciences field, plus at least three years of experience with the most of the skills described. If there are gaps in your experience, you will be able to learn additional skills so that you can eventually assist in any part of the process. Ph.D. level applicants with substantial proteomics experience are welcomed. Experience will include at a minimum, sample preparation (in-gel digestion), operating LC-MS equipment, setting up database searches for qualitative proteomics experiments.
Full Time/Part Time
Full time, 100% FTE
All applicants should submit the following in one .pdf file: cover letter, curriculum vitae/resume and contact information for three references that can describe your relevant experience and expertise. Applications will be considered as received, and the position will remain open until filled. Please direct all inquiries and correspondence to Mary Flores (FloresM@umkc.edu), School of Biological Sciences, University of Missouri-Kansas City.
The University of Missouri system benefits package are good, and pay will be based significantly on your experience and capabilities. Criminal history background check will be conducted. Refer to the facility website to see the available equipment and services currently provided (http://sbs.umkc.edu/research_proteomics.cfm). Interviews can be set up to take place at the annual meeting of the American Society for Mass Spectrometry in Indianapolis (June 2017), or by scheduling an onsite interview.
For questions about how applicants apply, please call 816-235-1621, or if you are experiencing technical problems, please call 855-524-0002.
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