The Department of Biomedical Engineering is seeking a highly motivated Research Technologist for the laboratory of Jamie Spangler in the Translational Tissue Engineering Center at the Johns Hopkins School of Medicine. The Research Technologist will help to manage daily operations and support research in molecular immunoengineering.
The Spangler Lab wishes to recruit qualified individuals to support our group's research, which is focused on applying structure-guided biomolecular engineering to develop novel platforms for the design of protein therapeutics to treat immune diseases such as cancer, chronic infection, and autoimmune disorders. The Research Technologist will be trained in cutting edge technologies in protein biochemistry, structural biophysics, molecular evolution, and translational immunology, have access to state-of-the-art resources and equipment, and contribute to high-impact research at the interface of engineering and medicine.
Primary Duties and Responsibilities: Direction of research projects under the general supervision of the faculty investigator and senior lab members: Protocol development and assay design. Critical analysis of data. Identification and troubleshooting of situations requiring special attention. Lab management and organization. Purchasing, operating, and maintaining lab equipment and supplies. Weekly presentation of results to the lab. Design of figures and preparation of text for reports and publications.
The work will involve a wide range of techniques including: Protein expression and characterization X-Ray crystallography, Molecular biology/cloning Molecular evolution (Yeast and phage display platforms) Culture of primary cells and established cell lines Cell-based activity studies (Flow cytometry, western blotting, ELISA) Animal models of immune disease
Bachelor's degree in Bio-engineering, Chemical Engineering, Biology, Chemistry, or a related field required. Relevant research experience in biochemistry, molecular and cell biology, and biophysics is preferred.
Additional Knowledge, Skills and Abilities: The successful candidate will be proficient in best lab practices, exhibit strong communication and management skills, and demonstrate the ability to work independently.
Working Conditions: Many department laboratories operate 24/7 with schedules on day, evening, or night shift. Rotating schedules may include weekend work and holiday assignment.
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