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The Wolchok lab at Memorial Sloan Kettering Cancer Center and the Parker Institute for Cancer Immunotherapy seeks a collaborative senior bioinformatician to lead the analysis of high-throughput sequencing data from mouse and human tumors, including WES, WGS, and RNA-seq. Must be willing to learn, apply, integrate, and develop new statistical models and computational algorithms, as well as manage and direct a small group of junior bioinformaticians in the lab. Ability to work in an interdisciplinary environment with clinicians and biologists required, as is an interest in investigating clinically relevant interactions between cancer and the immune system.
PhD in Bioinformatics/Computational Biology
Expertise in tumor exome analysis:
Experience performing mutation calling using common variant callers (Strelka, Mutect Varscan, SomaticSniper) and sequence analysis packages (picard, GATK) and similar programs in a cluster or cloud-based setting.
Ability to interpret tumor exome mutation calls in a biological and/or clinically relevant manner
Familiarity with HLA typing from exome sequence (e.g. seq2HLA, Optitype) and neoantigen prediction algorithms, with opportunity to learn from other bioinformaticians in the group if experience in this area is limited.
Knowledge of biological data analysis:
Familiarity with extracting data and performing analyses from common databases in the context of immunology (e.g. TCGA, ICGC, IEDB, cBio).
Facility with RNAseq differential expression analysis
Ability to communicate results and create publication quality figures to clinicians and collaborators through multiple means (e.g. Jupyter notebook, Tableau, Prism, ggplot2, matplotlib, cytospade etc.)
Familiarity with biostatistical methods (including survival analysis and time series analysis) and visualization of wet lab data (e.g., flow cytometry) preferred
Minor wet lab experience and in vivo/vitro experimental design preferred.
Programming experience in R and a separate programming language (e.g. C/C++, Python, Perl, etc.)
Experience with the Unix environment, bash scripting and parallel computing.
MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.
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As one of the world's premier cancer centers, Memorial Sloan-Kettering Cancer Center is committed to exceptional patient care, leading-edge research, a...nd superb educational programs. The close collaboration between our physicians and scientists is one of our unique strengths, enabling us to provide patients with the best care available today as we work to discover more effective strategies to prevent, control, and ultimately cure cancer in the future. Our education programs train future physicians and scientists, and the knowledge and experience they gain at Memorial Sloan-Kettering has an impact on cancer treatment and the biomedical research agenda around the world.