Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Senior Scientist to work on the Neuroimmunology team focused on discovering, validating and developing immunomodulatory therapies for the treatment of Multiple Sclerosis (MS). This is a laboratory based position that will include leading project teams and efficiently interacting with internal and external groups to initiate new drug discovery programs and advance ongoing projects. The candidate must have training and experience in neuroimmunology, including cell and molecular biology, -omics and bioinformatics data mining and other approaches to identify and validate targets and pathways.
KEY TASKS & RESPONSIBILIITES
Lead projects of high complexity as a project team leader, driving them from exploratory to first-in-human studies.
Establish in vitro cell-based models of immune cell interactions including activation assays, antigen specific assays using intracellular cytokine or tetramer staining, and flow cytometry.
Generate and analyze dynamic cellular gene signatures and mine databases to identify new targets and pathways.
Conduct in vivo experimental work in animal models of MS, e.g. EAE and other immune-driven models.
Interact with cross functional groups and other Neuroscience team members in the US and EU.
Efficiently collaborate with scientists within various departments including Chemistry, DMPK, translational sciences and Immunology and Inflammation researchers in the US and Europe.
Prepare and communicate results at external meetings and in publications of high quality.
Establish and maintain a scientific network external to the company to access cutting edge technology and information to advance internal efforts.
Ph.D. in Neuroimmunology, Immunology or related field with postdoctoral training; 3-5 years of research experience in MS and/or neuroimmunological aspects of neurodegenerative diseases. Biopharma experience strongly preferred.
Comprehensive understanding of immune cell biology, nervous system-immune system interactions, and pathology of MS and relevant preclinical animal models.
Strong track record of publications in neuroimmunology, immunology, MS and/or related areas.
Ability to isolate subsets of immune cells and establish primary cultures, including co-culture.
Experience in in vitro pharmacology: dose response, PK/PD, kinetics, mechanism of action, proof of concept studies.
Experience in appropriate biochemical assays.
Excellent presentation and writing skills.
Excellent speaking, reading and writing skills.
Strong analytical and organizational skills.
Ability to meet aggressive timelines and deliverables in a collaborative environment.