A POSTDOCTORAL “HORMEL FELLOW” position is available immediately under the direction of Dr. Yibin Deng in the Department of Cell Death and Cancer Genetics at The Hormel Institute.
Our laboratory is interested in the signaling pathways that contribute to p53’s function in tumor suppression. The focus of our research is to understand how wild-type p53 controls apoptosis, senescence, autophagy, and metabolism in pre-cancerous and cancerous cells, and how p53 mutations that disrupt these processes impact tumor development and cancer therapy in cancer patients. Our goal is to use various biochemical and genetic approaches (including generation of innovative mouse models that faithfully recapitulate the salient features of human cancer) to explore key signaling pathways that allow cancer cells to escape p53-mediated tumor surveillance (Deng et al., Nature. 2009; Deng et al., Nature Reviews Cancer. 2008; Deng et al., Cell. 2003; Deng et al., Genes Dev. 2002). Recent publications published in Cell Reports (2014), Can Prev Res (2015), and EBioMedicine (2016). In addition, we have been using a combination of genomic and proteomic analyses of cancer, computational modeling of cancer pathways, RNAi- and CRISPR-Cas9-based screening and functional assays in cell culture and mouse cancer models to identify crucial signaling pathways that are linked to tumorigenesis. Our ultimate goal is to identify novel targets that can serve as a means to selectively kill cancer cells.
About the Department
The Hormel Institute, a biomedical research center of the University of Minnesota, was established in 1942 and has an excellent reputation and long history for producing world-class medical research. The Institute’s research success has resulted in a second major expansion of its research facilities and includes an additional new state-of-the-art laboratory building that opened in January 2016. The Hormel Institute offers its research scientists complete access to state-of-the- art cutting edge equipment that includes a cryo-electron microscope (Titan Krios and Tecnai G2 Spirit Biotwin); FACS cell sorter; confocal microscopy; flow cytometry; protein crystallography robotics and defraction system; nano-HPLC-AB SCIEX triple TOF 5600 mass spectrometry; Leica tissue processor, embedder and microtome; real-time PCR instrumentation; a Blue Gene/L and 3 racks of Linux GPU supercomputers for computational biology and bioinformatics; spectrophotometers; and Western blot imagers.
*THE HORMEL INSTITUTE IS LOCATED IN AUSTIN, MN, APPROXIMATELY 35 MILES SOUTHWEST OF ROCHESTER, MN, AND APPROXIMATELY 100 MILES SOUTH OF MINNEAPOLIS/ST. PAUL.*