The Department of Chemical and Systems Biology is seeking a Life Science Research Professional 2 to perform more complex functions and activities involved in defined research projects, and independently conduct a portion of the research project(s). We are looking for an exceptional candidate to join a dynamic, collaborative team using a multidisciplinary approaches to understand how cells maintain genome stability and prevent the accumulation of mutations through control of the DNA damage response, replication and transcription. Responsibilities include planning, managing, and executing experiments in collaboration with the PI and the rest of the research team, using modern molecular and cell biology techniques; developing new assays or modifying existing assays; analyzing data and modifying experiments as needed; employing molecular and protein biological techniques; organizing and maintaining the laboratory. On the job training in specific techniques will be provided. The Life Science Research Professional 2 will assist in supervising and training new staff and students on techniques as necessary and would assist with lab management duties such as ordering supplies, maintaining lab records, equipment and protocols and adhering to all Stanford safety regulations. Familiarity with techniques such as ChIP and ChIP-seq and genomic data analysis is highly desired as is experience with CRISPR-Cas9 systems. Successful candidate must have good organizational and communication skills and possess the ability to learn quickly and work independently.
Perform complex (lab and/or field) experiments for a major portion of the research project. Maintain detailed records of experiments and outcomes. Interpret and analyze results, often where few guidelines exist. Based on prior results, contribute to development of new research protocols and procedures or adaptation of existing protocols. Make recommendations on plan design and/or research direction to principal investigator. Work with health and safety department to ensure lab complies with regulations and all required trainings. Participate in multidisciplinary teams across different faculties or schools. Oversee supply and equipment budget under supervision of principal investigator or business manager. Perform ongoing literature review to remain current with new procedures and related research; present findings for lab work group. Contribute substantively to the preparation of papers for publication, especially in the results section. May contribute to publication of findings and present ongoing work and findings to colleagues at academic conferences. Supervise (either formally or informally) staff or students as needed, including oversight and instruction on techniques, as well as consultation on project work. Serve as technical resource for other research staff. Perform general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
* - Other duties may also be assigned
Proficiency with the following techniques desired: o Molecular biology (cloning, protein assays) o Animal cell culture work o Protein expression and biochemistry
Experience with ChIP, ChIP-seq and genomic data analysis is strongly desired Familiar with use of databases and online molecular biology tools. Experience using CRISPR-Cas9 systems Experience with advanced image analysis and microscopy Knowledge and interest in the biology of chromatin-templated processes, including DNA replication, DNA transcription and DNA damage processing
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and three years of related experience, or Master's degree.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED): Comprehensive understanding of scientific principles. General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications. Strong analytical skills and excellent judgment. Ability to work under deadlines with general guidance is essential. Excellent organizational skills and demonstrated ability to accurately complete detailed work.
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds. Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts. Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls. Must have correctible vision to perform duties of the job. Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours. Ability to lift heavy objects weighing up to 50 pounds. Ability to work in a dusty, dirty, and odorous environment. Position may require repetitive motion.
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens. May require work in an environment where animals are used for teaching and research. Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present. Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator. May require extended or unusual work hours based on research requirements and business needs.
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Stanford University is an equal opportunity employer and is committed to increasing the diversity of its faculty. It welcomes nominations of and applications from women, members of minority groups, protected veterans and individuals with disabilities, as well as from others who would bring additional dimensions to the university’s research, teaching and clinical missions.