This NIH funded laboratory investigates the molecular and cellular determinants of alloantigen specific tolerance using murine models of cardiac and pancreatic islet transplantation. Specific investigations involve the determination of mechanisms responsible for remodeling of secondary lymphoid organ structure, and how those mechanisms drive T cell migration, differentiation, and fate determination. The molecular focus of the investigations is directed to chemokines, chemokine receptors, cytokines, sphingosine receptors, lymphotoxin, and stromal fibers. Specific cellular elements include regulatory suppressive T cells, effector T cells, vascular and lymphatic endothelial cells, stromal cells, and dendritic cell subsets. Techniques include heavy reliance on in vivo animal models, migration and trafficking assays, real time imaging and advanced microscopy, multicolor flow and sorting, and a variety of molecular techniques for proteins and nucleic acids.
Warren KJ, Iwami D, Harris DG, Bromberg JS, Burrell BE. Vascular basement membrane proteins laminin alpha 4 and laminin alpha 5 differentially influence CD4+ T cell lymph node trafficking and allograft fate. J. Clin. Invest. 2014; 124:2204-2218.
Xiong Y, Ahmad S, Iwami D, Brinkman CC, Bromberg JS. T-bet regulates natural Treg afferent lymphatic migration and suppressive function. J. Immunol. 2016; 196:2526-2540.
Brinkman CC, Iwami D, Hritzko MK, Xiong, Y Ahmad, Bromberg JS. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration. Nature Communications 2016; in press.
Please send letter of interest, your contact information, CV, and list of three references to:
Jonathan S. Bromberg, MD, PhD Professor of Microbiology and Immunology Center for Vascular and Inflammatory Disease Transplant Program University of Maryland 29 S. Greene St., Suite 200 Baltimore, MD 21201 firstname.lastname@example.org 410-328-0008
Successful candidates will have at a minimum a recent PhD in immunology or a highly related biomedical field, demonstration of success in publication and presentation, and familiarity or expertise in many of the techniques utilized by the lab.
The University of Maryland, Baltimore is an Equal Opportunity, Affirmative Action employer. Minorities, women, individuals with disabilities and protected veterans are encouraged to apply.
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