Posting Summary: The Department of Pediatrics at the University of Virginia is seeking a Research Scientist to work in the Division of Pediatric Hematology/Oncology under the supervision of Dr. Daniel W. Lee.
The successful candidate will supervise and perform both basic and translational research aimed at developing novel chimeric antigen receptor (CAR) T cell therapies for children with cancer. The candidate will generate pre-clinical data in xenografts for CARs that have already been developed and will work with Dr. Lee to design new CARs. Emphasis will be in childhood leukemias and brain tumors (eg: medulloblastoma, diffuse intrinsic pontine glioma). In addition, the candidate will interrogate the cell signaling mechanisms resulting in the supra physiologic activation of CAR T cells with the aim of modulating these signals to control efficacy, proliferation and toxicity. Work will center around human specimens treated on a CAR T cell trial and in immunocompetant murine models.
The incumbent will also be expected to actively participate in lab meetings, present results at national/international meetings and participate in endeavors to publish the results of his/her work.
A PhD or MD is required at the time of hire. Experience performing bench-top and mouse experiments are required. Previous experience in lenti- and/or retroviral vector design is preferred.
To apply for the position please visit https://jobs.virginia.edu and search on Posting Number 0619129 or visit: https://jobs.virginia.edu/applicants/Central?quickFind=79576. Complete a candidate profile online, attach your curriculum vitae and contact information for three references.
The position will remain open until filled.
The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans and persons with disabilities are encouraged to apply.
Founded by Thomas Jefferson, the University of Virginia opened in 1825 as the nation's first public university. A longstanding dedication to preeminence in both scholarship and teaching; top ranking in global satisfaction, collegiality and work/family issues on the COACHE survey of early career faculty; a commitment to excellence that is integrally connected with diversity and a broad array of ben...efits make the University of Virginia a prime choice for both faculty and staff. The University of Virginia is located in the small cosmopolitan city of Charlottesville near the Blue Ridge Mountains, 70 miles from Richmond and 110 miles from Washington, D.C. The University of Virginia remains the No. 2 best public university in the 2013 edition of the U.S. News and World Report rankings. In the 14 years since U.S. News began ranking public universities as a separate category, U.Va. has ranked either No. 1 or No. 2. U.Va. continues to rank in the Top 25 among the best of all national universities, public and private.