| Summary Description: Postdoctoral positions are available to study mechanisms of epigenetic inheritance and cancer epigenetics at Columbia University's Institute for Cancer Genetics. Candidates who have a solid background in molecular biology and biochemistry and are highly self-motivated in research are encouraged to apply. Experience in yeast, mouse embryonic stem cells and human cancer cells are preferred for these positions.Interested candidates should apply online and also email their CV and the names of three references to email@example.com and/or firstname.lastname@example.org. RESEARCH INTEREST: Our first long-term goal is to determine how epigenetically determined chromatin states are inherited during S phase of the cell cycle. Towards this goal, we have been using the budding yeast, mammalian cell culture and mouse as models to address this fundamental, but poorly understood process. Our second long-term goal is to elucidate how epigenetic alterations contribute to tumorigenesis. We are focusing on analyzing how histone variant H3.3 mutations frequently found in pediatric brain and bone tumors reprogram epigenetic landscape and drive tumorigenesis. SELECTED PUBLICATIONS: 1. Fang* D, Gan* H, Lee* J, Han* J, Wang* Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu R, Westendorf JJ, Zhang Z (2016) The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science, in press. 2. Yu C, Gan H, Han J, Zhou Z, Farrugia G, Ordog T, and Zhang Z (2014) Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall. Molecular Cell 56, 551-63. 3. Han, J, Zhang H, Zhang, H, Wang, Z, Zhou, H, Zhang Z (2013). A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. Cell 155, 817-829.|
Minimum Qualifications: Eligible candidates must have a PHD doctoral degree in one of the following: Biochemistry, Molecular Biology, Genetics or Cancer Biology. Strong competence in yeast, mouse ES cells or human cancer cells; a record of productive and collaborative research; and excellent communication skills in written and spoken English is required.
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