Summary Description: A post-doctoral research scientist position is available in the Department of Medicine, Division of Cardiology, with the Reilly group at Columbia University. The successful candidate will have grounding in human genetics, functional genomics and molecular biology in pursuit of the genetic and molecular basis of complex diseases. Ideally with training and experience in genetic discovery (e.g., GWAS, exome/DNA-seq, RNA-seq, ChIP-seq etc) and related functional model systems (e.g., human induced pluripotent stem cells, gene editing, humanized mouse models cell modes). He/she will pursue functional genomic studies of human loci for cardiometabolic traits. Projects are NIH-funded and require a post-doctoral lead on specific genetic loci for CAD and includes generation and analysis of cell and tissue specific genomic data (DNAseq, RNAseq, ChIPseq), cell signaling and biology in primary human vascular cell and hIPSC-derived vascular cells including gene-editing, and mouse models (knockout and transgenic) for vascular studies.
Minimum Qualifications: Requires a PhD, MD, PhD or equivalent doctoral training. Experience in human genetics, functional genomics and molecular biology including cell systems and mouse models of human cardiometabolic disease. Experience with analysis and bioinformatics of genome wide data (SNP-GWAS, exome/whole genome data, RNAseq, ChIPseq) e.g., in constitutional or cancer genomics; experience with primary cell and stem cell tools in functional genomics; experience with mouse models and in vivo phenotyping of vascular or metabolic traits. Comfortable in team science environment that includes laboratory, computational, biostatistical and clinical applications and interactions.An ability to work independently as well as in a strong team-science environment are required.
Preferred Qualifications: Prior post-doctoral experience (1-2 years) in relevant areas a plus but not required.
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Columbia University is an Equal Opportunity/Affirmative Action employer.
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