Summary Description: The Department of Pathology and Cell Biology at the Columbia University Medical Center is recruiting a Postdoctoral Research Scientist in the laboratory of Dr. Kevin Gardner. The incumbent will study the basic mechanisms of epigenetic gene regulation in breast cancer. The position will have an integrated focus on fundamental mechanisms of chromatin-based transcriptional control, including basic mechanisms of epigenetic regulation and enhancer control, combined with emphasis on the translational implication of the work in furthering efforts in diagnosis, treatment and prevention of breast cancer. This includes understanding the role of transcriptional cross-talk and intersections receptor-mediated signaling pathways in the control enhancer-mediate influence on gene expression. An essential component of these efforts includes developing omic perspectives that integrate next-generation sequencing with genomics, transcriptomics, epigenomics, proteomics and metabolomics. The projects will be supported by access to an established diverse cohort of breast cancer patient samples with deep next generation molecular genomic characterization for both gene and pathway discovery and translation application in diagnosis, treatment, and prevention.
Minimum Qualifications: Ph.D. or M.D. equivalent in areas of biochemistry, cancer biology, cell & molecular biology or related field.
Preferred Qualifications: A proven track record of publication in epigenomics, molecular biology, or stem cell biology with a combined strong interest and focus on basic mechanism of biology and their translational implications for disease incidence and progression is preferred. Expertise in the performance and analysis of ChIP-seq is required. Familiarity with CRISPR/Cas9 technology and ATTAC-seq analysis is highly desirable. Experience in murine model systems is strongly desired, but not essential. Familiarity with bioinformatic approaches and technologies in manipulating and interpreting deep sequencing data would be a significant advantage. We are looking for individual with a strong desire to work on fundamental research questions in cancer and chromatin biology. Those candidates with a proven research experience and a history of an ability to independently drive a project forward in an interactive environment, with willingness to provide mentorship to junior lab members, is highly desirable. Prior experience in patient derived xenografts approaches and technology (PDX) would be very competitive.
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