This NIH funded laboratory investigates the molecular and cellular determinants of alloantigen specific tolerance using murine models of cardiac and pancreatic islet transplantation. Specific investigations involve the determination of mechanisms responsible for remodeling of secondary lymphoid organ structure, and how those mechanisms drive T cell migration, differentiation, and fate determination. The molecular focus of the investigations is directed to chemokines, chemokine receptors, cytokines, sphingosine receptors, lymphotoxin, and stromal fibers. Specific cellular elements include regulatory suppressive T cells, effector T cells, vascular and lymphatic endothelial cells, stromal cells, and dendritic cell subsets. Techniques include heavy reliance on in vivo animal models, migration and trafficking assays, real time imaging and advanced microscopy, multicolor flow and sorting, and a variety of molecular techniques for proteins and nucleic acids.
Warren KJ, Iwami D, Harris DG, Bromberg JS, Burrell BE. Vascular basement membrane proteins laminin alpha 4 and laminin alpha 5 differentially influence CD4+ T cell lymph node trafficking and allograft fate. J. Clin. Invest. 2014; 124:2204-2218.
Xiong Y, Ahmad S, Iwami D, Brinkman CC, Bromberg JS. T-bet regulates natural Treg afferent lymphatic migration and suppressive function. J. Immunol . 2016; 196:2526-2540.
Successful candidates will have at a minimum a recent PhD in immunology or a highly related biomedical field, demonstration of success in publication and presentation, and familiarity or expertise in many of the techniques utilized by the lab.
Please send letter of interest, your contact information, CV, and list of three references to:
Jonathan S. Bromberg, MD, PhD
Professor of Microbiology and Immunology
Center for Vascular and Inflammatory Disease
University of Maryland
If accommodations are needed, contact Staffing & Career Services at 410-706-7171, Monday – Friday, 8:30am - 4:30pm EST. Maryland Relay can be accessed by dialing 711 (in-state) or 1-800-735-2258.
The University of Maryland, Baltimore is an Equal Opportunity/Affirmative Action Employer. Minorities, women, veterans and individuals with disabilities are encouraged to apply.
Organization: SOM Basic Science Departments
Job Posting: Feb 8, 2017
Internal Number: 48580
About University of Maryland, Baltimore
The University of Maryland, Baltimore (UMB) is the State's public health, law and human services university devoted to excellence in professional and graduate education, research, patient care, and public service. As a diverse community of outstanding faculty, staff and students, and using state-of-the-art technological support, we educate leaders in health care delivery, biomedical science, global health, social work and the law. We emphasize interdisciplinary education and research in an atmosphere that explicitly values civility, diversity, collaboration, teamwork and accountability. By conducting internationally recognized research to cure disease and to improve the health, social functioning and just treatment of the people we serve, we foster economic development in the City, State, and nation. We are committed to ensuring that the knowledge we generate provides maximum benefit to society and directly enhances our various communities.