Professional Field The area of research will encompass cellular, molecular, and cancer biology as well as genetics, and immunology. Major projects include mechanistic studies related to oncology and responses of cancer cells and normal cells to radiation.
Duties/Responsibilities The Scientist will be responsible for a major component of one or more research projects and will assist in teaching laboratory techniques to students, post-doctoral fellows, or other Scientists as necessary. S/he also will contribute to animal care activities, lab maintenance, database support, and inventory. The area of research will revolve around radiation biology including effects of radiation on cancer and normal cells. The work is expected to include studies in vitro, but it could extend to transplantable tumors in mice.
The scientist will receive direct and indirect supervision by the PI and may be assisted by other scientists within the laboratory space. S/he is expected to work independently within the limits of his/her projects.
Examples of Work Performed (not an exhaustive list)
1. Developing research protocol 2. Collaborating with PI or Senior PRA 3. Collating abstract data from study participant charts or records 4. Validating quality of data elements/data editing 5. Preparing tissues, cell cultures, blood samples, etc. for testing 6. Preparing samples and detecting rare events using flow cytometry 7. Manipulating rare events after sorting 8. Deriving cancer stem cells and differentiation in vitro 9. Microscopic analysis 10. Measuring and monitoring gene expression (in mice, cells, and tumors) 11. Performing recombinant DNA work 12. Establishing tumor xenografts 13. Monitoring cell interactions 14. Modifying, testing, verifying, and analyzing research data 15. Preparing samples for analysis by various instrumentation 16. Performing experiments 17. Tabulating research data 18. Recording results of experiments 19. Preparing research manuscripts and research presentations 10. Developing and maintaining research databases 21. Conducting screens and assays 22. Performing studies as related to research project 23. Conducting literature searches 24. Training laboratory personnel in experimentation techniques 25. Diagnosing and problem solving in relation to the research project 26. Animal care related to research procedures if needed and as training allows 27. Purchasing (PeopleSoft) 28. Purchasing (University credit card) 29. Working with vendors, including investigating and comparing products and helping to negotiate price and/or conditions of purchase 30. Laboratory scheduling (Doodle, Google calendar) 31. Safety training and safety supervision
All required qaulifications must be documented on application materials.
Bachelor (BS or BA) degree in life sciences (Biology, Immunology, Genetics, Biochemistry, or equivalent) or Basic Sciences (Chemistry or equivalent) and one year of related experience or equivalent combination of education and work experience to equal five years.
Experience must include one year of laboratory experience, including mastery of tissue culture and sterile techniques and handling hematopoietic cells and cancer cells.
Computer skills with Microsoft Office applications are required.
A Masters (MS or MA) degree is desirable but not required.
Prior experience (>6 months) in a laboratory with a fundamental understanding of purchasing systems and experience communicating with vendors and other company representatives, supervising graduate and/or undergraduate students, scheduling and coordination of laboratory meetings, and overseeing laboratory safety.
Highly desirable skills include proficiency in contemporary cellular, molecular, and biochemical techniques, including, but not limited to fundamental knowledge of methods in flow cytometry, isolation of proteins and nucleic acids, cell culture, PCR, RT-PCR, immunoblotting, cloning, transfection/transduction, sequencing, immunoprecipitation, immunofluorescence, microscopy, and digital imaging. While training in handling and working with laboratory mice may be helpful, it is not required.
Familiarity with software for sequence design and analysis, flow cytometry, database management, and coding is preferred.
Demonstrated capability in directing the technical aspects of a research project is preferred.
The position requires some physical activity, including receiving packages, occasionally lifting heavy objects and boxes, careful fine dissecting and separation of tumor or diseased tissues from normal tissues, pipetting of very small quantities of material, and accessing equipment that may be located in tight comers and/or shelves or storage areas that are difficult to access. All possible accommodation will be made for individuals who have physical handicaps but can otherwise perform the duties described.
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.