Gilead Sciences, Inc. is a research-based biopharmaceutical company founded in 1987. Together we deliver life-saving therapies to patients in need. With the commitment and drive you bring to the workplace every day, you will be part of a team that is changing the world and helping millions of people live healthier, more fulfilling lives. Our worldwide staff of more than 6,300 people is a close community where you can see the tangible results of your contributions, where every individual matters, and everyone has a chance to enhance their skills through ongoing development. Our scientific focus has resulted in 16 marketed products that are benefitting hundreds of thousands of people, a pipeline of late-stage drug candidates and unmatched patient access programs to ensure medications are available to those who could otherwise not afford them. By joining Gilead, you will further our mission to address unmet medical needs and improve life by advancing the care of patients with life-threatening diseases.
- Design and execute/run reaction sequences
- Define process development for chemical intermediates and drug substances
- Perform chemical reactions, isolations, separations, purifications, and crystallizations
- Conduct route scouting, reaction optimization, and scale-up demonstration
- Write concise procedures and reports to enable successful technology transfers
- Participate in group and project teams meetings and communicate results in a team-based environment
The candidate must be skilled in the art and practice of modern synthetic and mechanistic organic chemistry. - - Familiarity and competence with modern spectroscopic methods applied to structure determination including 1H and 13C NMR, infra-red spectroscopy, and mass spectroscopy are required.
- Experience in the use of preparative silica gel chromatographic separations as well as analytical separations involving HPLC and GC is required.
- Practical experience in multi-step syntheses is preferred.
- Experience with spreadsheet programs such as Microsoft Excel and database software such as SciFinder is a plus.
Responsible for developing chemical processes for the manufacturing of drug substances. Familiar with Pilot Plant operations and able to write master batch records and safety summaries with limited supervision.
Pays particular attention to avoiding reactions and processes that do not scale well, such as distilling to dryness and flash chromatography.
May suggest alternative chemistry including step optimization and new route selection. Gains a better understanding of how impurities are formed, tracked and purged throughout the subsequent processing.
Works in collaboration with more senior scientists or scientific directors to advance the development of economical, state-of-the-art techniques to isolate, characterize, purify and mass-produce substances.
Works on complex problems where analysis of situations or data requires evaluation of intangible variables, requiring regular use of ingenuity and creativity.
Advises members of project teams in the initiation and execution of laboratory experimentation, considering economic, regulatory and safety factors.
Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.
Makes contributions to scientific literature and conferences through publication and presentation of research results.
Maintains full working knowledge of state-of-the art principles and theories, applying such knowledge to the direction that supports Company interests.
Demonstrates technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design and strategy.
Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
Demonstrates excellent verbal communication skills and interpersonal skills.
Demonstrates collaborative communication and problem solving spirit.
3+ years of experience and PhD in a relevant scientific discipline.
BS or MS degree with extensive industry experience.
If this is not the right move for you now but remain interested in a career at Gilead Sciences please connect with us via our talent community:  https://gilead.avature.net/Gilead
Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercialises innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.
Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. We strive to transform and simplify care for people with life-threatening illnesses around the world. Gilead's portfolio of products and pipeline of investigational drugs includes treatments for HIV/AIDS, liver diseases, cancer, inflam...matory and respiratory diseases, and cardiovascular conditions.Our portfolio of marketed products includes a number of category firsts, including complete treatment regimens for HIV infection available in a once-daily single pill and the first oral antiretroviral pill available to reduce the risk of acquiring HIV infection in certain high-risk adults.